Sunday, March 22, 2015

Intraoperative PNS

One of the more frequently used tools in the OR is the peripheral nerve stimulator (PNS). The battery powered device delivers depolarizing current via two electrodes. When properly placed, it can be used to evaluate the level of neuromuscular blockade in a patient and tell us when it is appropriate to use neuromuscular blockade reversal agents. One of the more commonly used devices is pictured below. The device is pretty intuitive to use, so I won't go into too many details. This tutorial is more focused on proper lead placement to optimize your results. Just know that the black represents the negative lead and the red represents the positive lead.

Early on in my education, I felt like it was one tool I was not using properly. In particular, my lead placement was kind of all over the place. There were often times when I would be getting no PNS response only to have the surgeon yelling about the patient moving moments later. Briefly, I am going to go over how to properly place the leads using the more common nerves. These are not the only nerves you can use, but they are utilized often because they exhibit a visible motor reaction when stimulated, are close to the surface of the skin, and are often easy to access during a variety of surgeries.

Ulnar Nerve: In general, this is your best option for evaluating a patient for extubation and reversal of neuromuscular blockade. When giving muscle relaxants, this nerve response will be the first to go and last to return. That means it is not a great indicator for intubation but gives a larger margin of safety when determining status for reversal and extubation.

For proper PNS, extend the arm in a relaxed state with the palm up. The two electrodes will be placed over the path of the ulnar nerve. The more distal and negative electrode is placed at the level of the wrist on the ulnar surface at the flexor crease. The positive lead is then place a few cm proximal to the first. See the image below.

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Facial Nerve: When giving muscle relaxants, this nerve is one of the last responses to disappear and one of the first to reappear. For this reason, it can be reliably used for intubation (not something you will often see) but isn't the standard of care for extubation and reversal, even though the onset, duration, and sensitivity of the muscles stimulated are the same as most of the respiratory muscles.

The positive electrode is placed on face at the outer canthus of the eye. The negative lead is then attached a few cm beloe, at the same level of the tragus of the ear. See picture below.

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Posterior Tibial Nerve: This nerve is often used in surgeries when the head of the bed is turned 180 degrees (craniotomy, ENT, etc). Sensitivity should be very similar to that of the ulnar nerve.

The negative electrode is placed more distally, just posterior to the medial malleolus. The positive electrode should be placed a few cm above the first, more proximal. See image below.

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Nasal Intubation Guide

Introduction 

As a student, I found it very difficult to find a good guide online or in text books on how to setup and perform nasal intubations. This seemed very strange to me, as it is one commonly performed airway management techniques, especially in dental procedures and surgeries involving the mandible. Without knowing what to set up or how to prepare, nasal intubations always seemed like a very daunting task. This tutorial is here to bring it down to size. It really isn't much more difficult than a standard laryngoscopy, as long as you know what to do and how to prepare. This tutorial is here to show you a common setup and describe the procedure itself. Follow these simple steps and you'll be able to safely secure your patient's airway while providing adequate surgical exposure for the surgeon.

Setup

There are a few items from a standard ETT setup that you will want to make sure you have ready to go.
  • Appropriately sized blade with working handle - Mac 3, Mac 4, Mil. 2, Mil 3. 
  • Appropriately sized oral airway - It is vital that we are able to mask ventilate our patient.
Here's where things start to change up. There are a number of different items. Sometimes you can find them in the OR, other times you may need to go to pharmacy or the anesthesia techs for help.


  • Pharmacy Nasal Pack - At some hospitals you can go to pharmacy and ask for a pack by name. They may have all the components compiled already, however, in some hospitals you may just have to ask for the individual components. 
  1. Afrin nasal spray - This spray is an alpha adrenergic agonist. It causes vasoconstriction of the vessels in the nasal cavity to reduce the risk of bleeding. As you will see shortly, it can also be used to help us identify which nasal cavity in which to place the ETT.  
 
  1. Lidocaine Jelly - Many practicioners will use this as lubricant for nasal trumpets and ETT. If not available, you can use a standard water based lubricant. 
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  • Magill forceps - They make a smaller version for pediatric patients. This will later be used to help advance the tube through the vocal cords.  
  • Nasal trumpets of varying size - Some attendings like to use these to dilate out the nasal cavity before passing the ETT. If you look at the back of the packaging, usually the outside diameter will be labeled in mm. In the picture below, the size is shown as 9.3mm. The outside diameter of the ETT is usually listed on it's package as well. I like to compare the two and have one nasal trumpet with an OD just smaller than the ETT and then one about the same size OD or slightly larger. Before going to get the patient, you can cover the trumpets in the lidocaine jelly and leave wrapped in the package. 
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  • Nasal RAE endotracheal tubes - The ETT's are designed to pass through the nasal cavity, through the vocal cords, and can be secured out of the surgical field. A tube is pictured below. The sizing of nasal rae tubes generally follows the same guidelines as regular ETT's. It is a good idea, however, to have a size above and below what you anticipate using, just in case. 
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  • Warm bottle of NS - Before going to get the patient grab a warm bottle of NS from the core. If you don't know where to find it, ask one of the nurses, they should be able to tell you. Place the nasal rae tubes in the warm bottle of NS. It will make the tube more compliant ad easier to pass through the nasal cavity. 
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In the pre-op area

In adults, you can take the Afrin nasal spray and ask them to spray it in each nostril themselves. Pediatric patients wont likely tolerate this and you will likely have to use the spray during bag mask ventilation. If the patient is able to use the spray in the preop area, take a look at their nostrils afterwards. In general, the nostril with the smaller diameter after using the spray will have the larger nasal cavity and will be ideal for placing the tube.

This is also a good time to look for any CT scans or images that may be useful. For one, it will be able to accurately give you an idea of the size of the nasal cavities and if there are any obstructions. Secondly, if the surgery is fixing a mandibular fracture, it is likely the patient will have a limited mouth opening. A CT scan can give you an idea if this limited opening is due to pain (in which case general anesthesia will relax the patient and it shouldn't be an issue) or if it is a physical obstruction related to the injury (this is more a cause for concern and should be discussed with your attending. If it really an issue, nasal fiberoptic intubation may be your next option).

In the operating room

Initially, you will do things as you normally would in the OR. Get the patient situated on the OR table and connect the standard asa monitors and begin to pre-oxygenate. While preoxygenating, it is a good idea to make sure that all of your supplies are ready to go. Open your Magill forceps, remove the ETT from the warm saline and put some of the lidocaine jelly/lube on the end of it, and lube nasal trumpets if you have not done so already.

Push your induction drugs when you are ready and asses if the patient is asleep. Once asleep, bag mask ventilate as you normally would. Feel free to turn on some volatile agent. While masking, tape the eyes and spray some afrin in the nostrils if you did not do so in the preop area. After you have done this, pass the smaller nasal trumpet into the chosen nasal cavity. Give a few breathes with thi sin place. Remove this trumpet and place the larger one and give a few more breathes. The nasal cavity should now be properly dilated and you are ready for intubation.

Take the nasal rae ETT and introduce into the nasal cavity. The tube should enter at a 90 degree andle to the OR table. It should pass easily. If you meet resistance, try to reposition or consider using the other nostril. Don't advance the tube too far just yet. At this point, take you laryngoscope and DL as you normally would to gain a view of the vocal cords. Once you have your view, ask for someone to advance the tube until it is in your field of view, if it is not already. Now take the magill forceps and place them in the oral cavity. You will use them to grab and direct the ETT in the direction of the cords. Just be careful not to grab the cuff, as you can rupture it. ALWAYS grab distal or proximal to the cuff. Once in line with the vocal cords, again ask someone to advance the tube and visualize it as it passes through the cords. Remove the blade and forceps, inflate the cuff, and connect your circuit. Once proper placement is confirmed, you can secure the tube. Sometimes the surgeon will stitch it in place, so ask them if this something that they are going to do.


Saturday, March 21, 2015

Generalized Anesthetic Plan at TMC

Early in my education, I often had a difficult time looking at the bigger picture while taking care of patients in the operating room. It is easy to focus attention on skills and exciting surgeries when you are seeing many things for the first time and initially getting involved in airway and line management. One thing that really helped me was to write out anesthetic plans the night before and refine the details as you find out more information the next day when you arrive and have a chance to see the patient. To help you with this further, I have constructed a guide below describing how your setup and plan changes before a case as you learn more details about the specific case and patient. This post is very broad fairly basic. It is designed so that you should be able to understand it very early on in your education. You will learn that things are not always so straight forward and patient co-morbidities are more complex than they are portrayed to be here. However, this is a good starting place. Just be sure to ask yourself as you evaluate your patients in the preoperative area how each detail will impact your management, if at all. Take it step by step and it will being to come more naturally over time. As with many tutorials in this blog, most of the details are in reference to Memorial Hermann-TMC.

When arriving in the OR in the morning, the first thing I do before heading to my assigned room is grab a schedule. There are four main things I look at on the schedule that impact how I set up my room: The procedure being done, the age of the patient, the gender of the patient, and the weight of the patient (if listed).

M – Machine 
Machine check doesn’t change based on these factors.

S – Suction. 
Suction setup doesn’t change based on these factors.

M – Monitors 
For each case, I will automatically make sure we have standard ASA monitors BP cuff, pulse oximeter, and a 5-lead EKG. The other factors may change what else I have set up.
If the patient is much older, with possible underlying cardiovascular issues and/or the procedure listed is known to be invasive with the potential for lots of blood loss, I will make sure to have an arterial line set up and ready to go.

If it is a cardiac procedure or the procedure requires monitoring such as SSEP’s that would impact how much volatile agent we can use, I would consider getting a BIS in the room to help insure that the patient is not aware during the procedure.

A – Airway
At TMC I will usually have a general airway setup assembled on the anesthesia machine, but the factors on the schedule will impact what components I add and what I plan to use.

Is the patient male of female?: This will generally dictate whether I plan to use a 7.0 or 8.0 ETT. It will also impact what size oral airway I will plan to use.

What is the patient’s weight?: This will tell me if the patient is possibly obese and if I should get a video-scope in the room for intubation. If this is the case, I like to set up blankets on the bed to get the patient in a proper sniffing position, as well. Any advantage helps. Also, if it is a large male, I will consider using a MAC 4, as opposed to the Mac 3.

Does the procedure relate to a possible neck injury?: If it is imperative that we keep the patient’s neck stable, I can call for a glidescope or fiber-optic bronchoscope.

Is the indicated procedure working in the area of head and neck?: I can determine if I need to get any oral or nasal RAE tubes for intubation.

Is the procedure to be completed in the prone position?: If this is the case, I like to use benzo to help secure the ETT to prevent any dislodgment.

Is it a short, relatively non-invasive procedure?: I can consider just setting up and LMA of the appropriate size and plan to let the patient breathe on his or her own for the duration of the surgery.

Will the bed be turned 180 degrees for the procedure?: I can determine if I need to get an accordion for the ETT.

I – IV
I will always have a standard IV kit set up with a varying sizes of IV’s ranging from 16-20 gauge. In addition, I will prepare a few other things.

Is the patient coming from DSU?: If yes, I will not need to spike a bag of LR, since they will get one in the pre-op area.

Is the patient coming from ICU and/or is this an invasive procedure with potential for blood loss?: If this is the case, I will have a hotline spiked and ready to go to help with fluid resuscitation and to have the potential to give blood.

D – Drugs
Generally, I will set up syringes for Propofol, Lidocaine, Rocuronium, and Versed, and Fentanyl. It can be difficult to tell from the schedule if you will need a different set up from this other than if the patient is old enough that you might not want to give versed.

S- Special
Is it listed on the schedule that X-ray will be used? If so I’ll grab some lead from the tech room.
If it is an invasive procedure or if I know my attending likes it, I will consider getting some colloid in the room.


After the room is set up, I can finally head to the pre-op area to see the patient or to look up patient information if they are coming directly from their room or the ICU. This is the point when I can really gather some information and start to tailor a more specific anesthetic plan to the patient. Each section of the pre-op sheet will greatly impact our plan. This is usually the order that I actually go through the pre-op with the patient.

If not in DSU or pre-op holding and the patient is coming down from ICU, there is a chance that we will have to go and get the patient. If this is the case, I would go get a transport monitor from the tech room. I would also grab airway supplies and some emergency drugs in a large suction bucket to take with me incase anything happens during transport.

Verify surgery site- Once confirmed, you want to ensure that you don’t plan to have any IV’s or monitors that will interfere with the surgery or prep site.

Allergies- If the patient is allergic to latex or any medications you need to make sure that it is a true allergy and avoid these things. For medications, this means finding an alternative to what the patient is allergic to. For example, if the patient has a PCN allergy, I would consult with the surgeon and plan to avoid cephalosporins.

NPO Status – If the patient is deemed to have a full stomach (ate within a 8 hour period, is diabetic, is pregnant, or has a small bowel obstruction) and we are using a general anesthetic, the plan will automatically go to a GETA with a rapid sequence induction to prevent aspiration. This will include cricoid pressure, suction on hand, and succinylcholine (or rocuronium succ. Is contraindicated – ie. Elevated potassium levels, muscular dystrophy, recent burns, recent CNS trauma. It could also be advantageous to give pre-medications such as Pepcid, Reglan, and Bicitra.

Respiratory-

Recent cough or cold – May be better to postpone the surgery if it is an elective procedure. If not, be prepared that the patient may have a reactive airway more prone to laryngospasm and bronchospasm.
Asthma – If patient has asthma, and hasn’t used their inhaler that day, it may be wise to get an albuterol inhaler for them to use before heading back to surgery or giving a small dose of steroids. Keep a close eye on the capnograph waveform to see if patient has had an attack during airway management.

OSA – If patient has OSA and is non-compliant with a CPAP machine, they may live at a higher 
PaCO2 than the average person and it may take more to get them to breathe at the end of surgery. Also, prepare for a potentially difficult bag mask at the start and end of case, preparing oral and nasal airways as needed.

COPD - People with COPD are often smokers. Be prepared with suction for lots of secretions. These patients also live at a higher PaCO2 than the average person so it may be more difficult to get to breathe on their own at the end of the case. I would consider trying to limit my narcotics until the patient is breathing on their own, as to not further depress their respiratory drive. 

Cardiovascular –  

HTN – “Keep them where they live.” If a person normally has an elevated blood pressure, we want to keep them within 20% of that normal range, not 20% the average person’s value. This can be particularly important in people with chronic hypertension as they may have associated cardiovascular co-morbidities.

MI – It is important to ask what kind of treatments these patients have undergone, if they are symptomatic, and how recently they had a cardiac workup. If they have been doing well after their procedure, you may not have to be too concerned. Still may be advantageous to put in an A-line and induce with Etomidate to keep a tight control on BP and maintain perfusion to the coronary arteries. 

Pacemaker/defibrillator- Find out what type of implanted device they have and when it was last interrogated to ensure optimal function. Talk with the surgeon concerning electro-cautery to ensure patient safety. Make sure to have a magnet in the room to put the pacer in asynchronous mode or deactivate the defibrillator in the case of an emergency.

Murmurs/arrhythmias - Find out if they are on any medications for their arrhythmias and if they are currently in that arrhythmia. Know how to manage specific arrhythmias –ie keep a lower heart rate with people in A. fib to allow for adequate filling time of the atria.

Neurological

TIA/CVA – In patients with TIA or CVA, find out when they have occurred and what precipitated it. They can be on anti-coagulant drugs that you need to be aware of and you will need to ensure adequate blood flow to the brain through maintaining adequate volume status and keep blood pressures from dropping to low.

Neuropathy – It is important to find out about preexisting neuropathies and make note of them in the pre-op chart. In these patients you need to be conscious of positioning as to not worsen any neuropathy, create new neuropathy, or cause ischemia. Many neuropathies can originate from the head or neck. If this is the case, plan accordingly as to get video airway equipment and stabilize the head and neck during intubation if necessary.

Seizures – If a patient has a history of seizures, be sure to find out how often they have them and what medications they are taking. Be prepared with midazolam or propofol on hand if you need to, at any point, acutely treat a seizure. Also, many of the medications that people take for epilepsy can increase the metabolism of paralytics that we give. If needed for the procedure, you may have to give more than you would to many of your other patients.

Head injury – Does the patient have an increased ICP from an injury to the head? How is their mental status at the start of the case? If the patient has an already increased ICP or is at risk for an aneurism rupture, you need to take proper measures to ensure that you don’t further increase ICP – keep stimulation minimal during intubation, limit volatile gases, use positioning to your advantage, use diuretics in needed, mildly hyperventilate the patient, etc.

Gastrointestinal

GERD – If your patient normally has reflux, you need to find out if it is controlled and what kind of conditions normally trigger it. It is possible that they are at an increased risk for aspiration and your anesthetic plan needs to account for this. This can include things such as pre-medicating with Bicitra, Pepcid, and Reglan. Also consider doing a rapid sequence induction with cricoid pressure and starting with the patient in a reverse trendelenburg position.

Hiatal Hernia – Patients with hiatal hernias are increased risk for reflux and aspiration. Similar precautions as listed above need to be taken.

Metabolic

DM – Patients with DM often have lots of other comorbidities, so be conscious of this. It is important to check glucose levels and make sure they are in a normal range before heading back to the OR to improve pot-operative outcomes. Be conscious of neuropathies and unstable mandibular and alanto-occipital joints when positioning and do not give drugs that will raise the blood sugar, before you consider all of the outcomes.

Sickle Cell – Patients with sickle cell disease have a number of perioperative issues. Generally, they are poor temperature regulators, poor oxygen carriers, and tend to be hypercarbic and acidodic. Things we can do you help with this as anesthesia providers is give plenty of fluid and blood (sometimes preoperatively), keep a warm temperature in the room, utilize Bair Huggers, and use higher percent Fi02 if needed.  

Thyroid issues – Whether it be hyper or hypothyroidism, find out if the patient takes a medication regularly to keep it in control. If they are symptomatic be conscious of issues such as myxedema coma for hypothyroidism and thyrotoxicosis for hyperthyroidism and how to treat these (for example giving propranolol as the first line of defense for thyroid storm). Thyroid goiters can also potentially lead to difficult airway management. May be beneficial to use video scopes or fiberoptic bronchoscopes.

Steroid use – It is important to find out what kind of PO steroids patients are taking, why they are taking them, and what dose they take it at. If they take them on a daily basis, it may be wise to give a stress dose of steroids at the start of the procedure to ensure that their vascular smooth muscle has an adequate response to endogenous and exogenous vasopressors.

Kidneys

ESRD – There are a number of issues that are associated with ESRD patients that we need to be concerned with. One issue is access. It may be difficult to get IV access, so we need to make sure that we have as many working IV’s as we need. In addition we need to find out the patient’s dialysis schedule, when they were last dialyzed, and what their current volume status is. The amount of fluid that we can give them greatly depends on this. It is a delicate balance and we want adequate perfusion, but we don’t want to volume overload them. We will also need to check their electrolytes and use fluids – NS, Albumin, and PRBCs, as to not increase the levels of any electrolytes that we don’t want to. Patients may also be anemic due to lack of erythropoietin production. Finally, many drugs are partially metabolized and excreted by the kidneys and we want to avoid them due to adverse or prolonged effects (examples include merperidine and rocuronium). We need to find alternates to some of these drugs.

Liver

A number of drugs are metabolized in the liver and may have a prolonged effect in people with liver issues. People with liver issues may also have problems with coagulation and you may anticipate more bleeding during surgical procedures. People with liver disease may have perfusion issues, various organ comorbidities, and issues with their lungs. It is important to be aware of all of these.



Medications – It is essential to find out what medications they are normally on and if their medical issues are normally pretty well controlled. It is also crucial to find out what medications they have recently taken (that morning, the night before, earlier that week). The following can impact our anesthetic plan.

Chronic pain medications – Pain management can be potentially difficult in these patients and require increased amounts of pain medication. It helps to find out the frequency and amount of what they take to determine if this might be needed.

Diuretics – Used to control BP, they can sometimes have an effect on electrolytes. Be sure to check labs and get anything in order that might be necessary.

ACE inhibitors and ARBs – These BP meds can mess with a patient’s electrolyte levels and also make keeping up blood pressures increasingly difficult in the OR. We may need to give more fluids and use stronger, direct acting vasopressors.

Anti-epileptics – In these patients, we may need to give increased amounts of muscle relaxant in order to keep them paralyzed throughout the procedure. It is also important to find out when they last took the medication. On occasion, you will need to give a dose in the OR.  

ASA- If the patient has kept taking ASA within a 7 day period, they may have issues with coagulation. It is possible that you can cancel the surgery but if not, keep an eye on blood loss and be sure to communicate with your surgeon throughout the procedure.

Inulin/DM meds – It is important to check glucose levels regardless of when they took their medication but this should give you a better idea of where it will be and if you need to take measures to control it (ie giving insulin)

Steroids – Patients that take steroids on a regular basis may need a stress dose of steroids in order to keep management on their BP.

Social History-

Alcohol – If the patient has a history of chronic alcohol use, be conscious of associated liver issues. Also, they may have a higher tolerance and require larger doses of anesthetics. If they are acutely intoxicated, they will need less.

Smoking – Smoking can lead to a number of respiratory issues, as discussed above in the COPD section.

Illicit drugs – Certain illicit drugs can impact the effect of agents that we give as anesthesia providers. Be conscious of this and find alternatives. For example, in cocaine users, ephedrine will not be as effective because of depleted NE stores.

Surgical History –  If during past surgeries, does the patient have history of:
PONV – Consider scopolamine patch, numerous IV anti-emetics (Zofran, Decadron, phenergen, etc). Also consider limiting opioids and running a TIVA instead of using a full MAC of volatile agents.
MH – If patient or family has history of MH, we need to avoid volatiles and Succinylcholine. This means flushing the anesthesia machine and planning to run a TIVA. If paralytic is needed, stick to Rocuronium or others. 

Surgeries that impact the airway – Has the patient been trached before or had surgery that might impact the airway and make for a difficult mask or intubation. Be prepared for the difficult airway algorithm.

Severe issues with pain control- Explore options with long acting narcotics or talking with the block to team to see if there is a possibility for them to work on post-op pain control.


Labs – Part of the anesthetic plan can be deciding what labs to get and then deciding what to do once you have a chance to view those values.

CHEM 7 – These values will let you know how the patient’s electrolyte levels and balances are, as well as giving an idea of kidney function. These values will let you if it is safe to go into surgery, if you can anticipate cardiac arrhythmias, if you should use specific drugs, and if you should use specific types of fluids (ie NS over LR).

Coags. – These values can give you insight to liver function, how much the patient might bleed during surgery, and if you should run further tests, such as a TEG, in order to know which blood products would be appropriate to give during surgery.

H and H – Low H and H values can let you know if your patient is optimized for surgery or if you may need to type and screen, type and cross, or even have some blood available in the room.


Tests  - Similarly to labs, part of the anesthetic plan is deciding what type of tests to run on a patient and then making decisions based on the results you find.

CXR – Can let you know the current state of respiratory issues of patients and follow the plan as listed above in the respiratory section. Can also let you know of any masses that might hinder your management of airway and patient ventilation.

EKG & echo – Good to check these in older patients, patients undergoing stressful surgeries, and patients with previous cardiac issues. Will let you know the current state of their heart and how to proceed according to the cardiac section listed above. 

All of these components are combined to create an anesthetic plan that is specific to each patient and each surgery. 

Sunday, February 22, 2015

Pre-operative lab value tutorial

An important part of the preoperative evaluation is knowing when it is appropriate to order certain labs and how to evaluate their values. This can be, at times, very tricky even for anesthesia providers that have been practicing for some time. As a brand new student, seeing and evaluating all of these numbers can be very overwhelming. This tutorial is meant to help make evaluating labs a less daunting task. If nothing else, you should leave this page with the ability to recognize when lab values are outside of their normal range. Being able to know what to do, if anything at all, is another story and will eventually come with time. This is a starting point. If you see lab values that are out of the norm, use it as an opportunity to question why this is the case. Start a discussion with your instructor any chance you get, and it will start to make sense sooner.

Obviously we can’t order every available lab value for every single patient. For some people and surgeries, it would just be a waste. As with many things in anesthesia, it is important to weigh out the risk and cost versus the benefits when deciding what labs to order. Often times, you will not be the person ordering the labs, but it is something important to start thinking about; especially when it comes to acknowledging when an important value has not yet been determined for a patient. Ultimately lab values can aid you in confirming or excluding the presence of a disease, reduce risk, limit patient morbidity and mortality during surgery, and reduce costs. In addition to this, they can also be costly and time consuming to evaluate. You will have to use your best judgment to determine when you think they are needed.

BMP – Basic metabolic panel (AKA Chem-7)

Can potentially clue you in to information about fluid and electrolyte balances, kidney function, blood-glucose levels, and responses to various medications.

When might it be a good idea to order?
  • Underlying disease: HTN, Obesity, Heart failure, Kidney disease, liver disease, diabetes, CNS disease, endocrine disorders.
  • Using certain meds: diuretics, ACE inhibitors & ARBs, NSAIDs, Steroids, Digoxin, Aminoglycosides.

Image result for basic metabolic panel

Normal ranges of values:
  • Na – 135-145 mEq/L
  • K – 3.5-5.1 mEq/L
  • Cl – 95-109 mEq
  • HCO3 – 22-26mmol/L
  • BUN -7-22mg/dL
  • Cr – 0.5-1.4 mg/dL
  • Glucose(fasting) – 70-100mg/dL


A few values to focus on:
  • Cr: Creatinine – Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body. Men generally have more muscle, so their levels will be elevated. It is excreted unchanged by the kidneys, so provides a good evaluation of kidney function. It is inversely related to GFR. In geriatric patients, muscle mass decreases while kidney function is decreased, leaded to Cr levels remaining relatively unchanged in patients with relatively good kidney function.  

  • BUN – Blood Urea Nitrogen – Produced in the liver. It is directly related to protein catabolism and inversely related to GFR. Not always a reliable indicator of GFR, because protein catabolism may be impaired.

  • Bun:Cr ratio: Normally = 10:1.      >15:1 can be a sign of volume depletion in patients.  

  • K – Potassium – Generally speaking, elevated potassium levels are more of a concern than low levels. Low levels will rarely cause any issued or give reason for delayed surgery, unless they reach critical levels close to 2.0. In this case, they can be a cause for rhabdomyolysis. May be low in patients taking diuretics. Elevated levels on the other hand are more a cause for concern. You will often see elevated levels in end stage renal disease patients, patients taking potassium sparking diuretics, and patients taking ACE inhibitors or ARBS. Large increase can cause progressive EKG changes and eventually lead to cardiac arrest if not properly treated. Drugs such as succinylcholine can lead to increased levels of K, so be careful when using.

  • Glucose – Maintaining blood glucose close to the patient’s baseline can play an important role in preventing surgical site infection. Low glucose levels can make patients lethargic and lead to delayed emergence from anesthesia.


Coagulation Studies

Determine the clotting tendency of blood.

When might it be appropriate to order?
  • Known coagulation disorders, age >75, kidney or liver disease, diabetic, major procedure with lots of anticipated blood loss, planned epidural/spinal placement, taking anticoagulant therapy, pregnancy, trauma, sepsis.

Image result for inr ptt pt

Normal range of values:
  • PT – 10-12 secs
  • PTT – 25-35 secs
  • INR – 0.8-1.2 secs

What these values can tell you:
  • PT – Prothrombin time – Prolonged when there are issues with the extrinsic clotting pathway. Often see elevated times in patients with vitamin K deficiency, liver disease, and on warfarin therapy.

  • PTT – Activiated Partial Thromboplasin Time –Prolonged when a patient has issues with the intrinsic pathway. Often see elevated times in patients receiving Heparin, hemophiliacs, and Von Willebrand’s pateints.

  • INR – International Normalized ratio – Basically the same as PT. It is a standardized PT, designed to account for differenced in thromboplastin. Target for patients on Warfarin is generally 2.0-3.0.


CBC – Complete Blood Count

Provides information about the cells inside the patient’s blood.

When might it be a good idea to order?
  • Age >75, major procedure with lots of anticipated blood loss, chronic kidney or liver disease, anticoagulant use, bleeding disorders, clinical signs of anemia, trauma, infection, pregnancy.

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Normal range of values:
  • WBC – 4.0-10.5
  • Hemoglobin – Men: 14-18g/dL; Women: 12-16g/dL
  • Hematocrit – Men: 40.7 – 50.3%; Women: 36.1 – 44.3%
  • Platelets- 150 – 440
  • What these values can tell you:
  • WBC – Elevated levels can be a sign of infection or sepsis.
What these values can tell you:
  • Hemoglobin – Low values can tell you when a patient is anemic. In these situations, they may have recently been bleeding, are currently bleeding, or may have impaired kidney function. Elevated levels usually mean the patient is dry and may need fluid resuscitation with IV crystalloids.  

  • Hematocrit = about 3xHbg. Basically clues you in to the same things as listed above.

  • Platelets – The most important value in evaluating primary hemostasis. Below 150 is considered thrombocytopenia. Lower values are associated with increased intraoperative bleeding.

I hope this provides a good starting point and reference. Don’t be afraid to come back and review this material over time. It will continue to be useful throughout your time as a student and a practitioner. 

Commonly Used OR Antibiotics

Giving IV antibiotics prior to surgery is one of the more important actions we can take as anesthesia providers to prevent surgical site infection. Early on in your education it may seem like every patient gets 2 grams of Ancef, but this is certainly not always the case. This tutorial is designed to help you understand and know how much of what antibiotic to give in different scenarios. Pretty much everything listed here is based directly off of SCIP (Surgical Care Improvement Project) guidelines, which is considered the national standard. Some institutions and surgeons, however, have certain antibiotics, doses, or dosing schedules they prefer (usually still within guidelines), so always be sure to double check with the surgeon prior to administration. 

Below you will find tables showing which antibiotics are acceptable to use in different surgeries, their doses, and how often they should be re-dosed.


Anti-microbial agent Adult Dose Pediatric Dose Redosing Time
Ampicillin 2g 50mg/kg 2 hours 
Cefazolin (Ancef) 1g,2g, 3g (over 120kg) 30mg/kg 4 hours
Cefuroxime 1.5g 50mg/kg 4 hours
Cefotaxime 1g 50mg/kg 3 hours
Cefoxitin 2g 40mg/kg 2 hours 
Ceftriaxone 2g 50-75mg/kg NA
Ciprofloxacin 400mg 10mg/kg NA
Clindamycin 600mg, 900mg  10mg/kg 6 hours
Fluconazole 400mg 6mg/kg NA
Gentamycin 5mg/kg 2.5mg/kg NA
Levofloxacin 500mg 10mg/kg NA
Metronidazole (Flagyl) 500mg 15mg/kg NA
Vancomycin 15mg/kg (usually in 0.5g incriments)  15mg/kg 12 hours


Type of Surgery Prefered Antimicrobial  If Beta-Lactam Allergy 
Cardiac & Vascular Cefazolin Clindamycin or Vancomycin
Colon Cefoxitin Flagyl or Cipro
Gen. Surgery Cefazolin Clindamycin or Vancomycin
Gynecological Procedures Cefoxitin Flagyl & Gent; or Flagly & Cipro 
Neurosurgery Cefazolin Clindamycin or Vancomycin
Orthopedic Cefazolin Clindamycin or Vancomycin


All antibiotics listed, with the exception of Vancomycin (2 hour window), should be administered within a 1 hour window prior to surgical incision. Within half an hour is considered even better. If the dose is prior to the one hour window, discuss with your surgeon and attending about giving another dose.

Try and commit the more commonly used antibiotics to memory: Ancef, Vancomycin, Clindamycin

    
A few good useful pieces of information to know about antibiotics:

  1. Antibiotics are one of the more common medications that patients have immune-mediated reactions to – rash, pruritis, bronchospasm, anaphylaxis.
  2. Certain antibiotics, most notably Vancomycin, can cause non-immune mediated histamine releases, triggering symptoms that look very similar to an anaphylactic reaction. To avoid this with Vancomycin, put in a 100cc or 250cc bag of NS and run in over an hour. You will come across a number of antibiotics in our career, many that you are unfamiliar with. If you are unsure whether or not to run it in slowly, check the vial or contact the pharmacy.
  3. You will often come across surgeons and anesthesiologist that like to avoid Cephalosporins (such as Ancef) in patients with Penicillin allergies because concerns of cross reactivity. The truth is, there is a very low incidence of patients having an anaphylactic reaction to cephalosporins with a penicillin allergy. However, it is still reasonable to avoid in these situations.   
  4. Some antibiotics can cause ototoxicity (issues with your hearing) – particularly Vancomycin and Gentamycin.
  5. Some antibiotics can be nephro-toxic – ie. Gentamycin. 


Commonly Used Drug Infusions

Before even arriving at CWRU-MSA Houston, everyone is assigned a drug card with doses and concentrations of drugs you commonly encounter in the OR. This card is very helpful for an extended period during your training, however, it is just a starting place. One thing that is not featured on the card that you commonly encounter in the OR are drug infusions. This is a basic tutorial that goes over some commonly used infusions, mostly pertaining to Memorial Hermann. It will also cover the concentrations and dilutions that are used for these infusions and how to do a basic setup with an Alaris pump. You may not encounter all of these early on in your training, but this can be a helpful tool to refer back to.

Pay close attention to the units. Most infusions will be run on a mcg/kg/min dose range with a few exceptions.  

Sedatives:
  • Propofol: Sedative-hypnotic agent that works through positive modulation of the GABA neurotransmitter.
    • TIVA: 100-200mcg/kg/min 
      • In these cases, for one reason or another, you are not running any volatile anesthetic. Propofol will generally be the main hypnotic agent making up for the lack of volatile. Dosing range varies on a number of factors including age and what other IV sedative/analgesic agents you are running.
    • Mild sedation: 25-75mcg/kg/min.
      • This dose range is seen in certain cases such as colonoscopies and EGD’s. At Hermann and the DDC, however, pumps are not used and the drug is titrated by hand.
    • Neuro cases: 25-75mcg/kg/min
      • In many neuro cases, propofol is run in addition to half a MAC of gas and a narcotic infusion. Necessary for intracranial surgery with necessary management of ICP and spine cases in which the surgeon is using neuro monitoring (SSEP’s & MEP’s).
    • Dilution: You can get 50ml or 100ml vials of propofol from the Pixis or pharmacy that come in 10mg/ml concentrations. No need to dilute. Just spike bottle and set to pump.
  • Precedex: Alpha-2 agaonist. Used in numerous settings. You will most commonly see it in the OR used for awake fiberoptic intubations, smoothing out the patient emergence, and running as an infusion along with a narcotic and half a MAC of gas during neuro cases (often in cases treating epilepsy where propofol is contraindicated because it hinders surgeon analysis of epileptic foci in the brain).
    • Initial Bolus: 1mcg/kg over 10 minutes.
    • Infusion: 0.2-0.7 mcg/kg/hr
    • Dilution: Precedex usually comes in one of two concentrations: The first is a 50ml bottle from the pharmacy @ 4mcg/ml. No need to dilute this bottle. Just spike bottle as is and hook to the pump. The second is in a 2ml vial @ a concentration of 100mcg/ml (a total of 200mcg per vial). Take these 2 mls and dilute into a 50ml bag of NS to get a final concentration of 4mcg/ml.  

 Pain Control:
  • Ketamine: Works really well for pain control, particularly in patients that take chronic pain medications or abuse narcotics. At pain level doses, I have never run into any issues with hallucinogenic side effects. Also works well to bolus the agent at around these same doses.  
    • Infusion: 0.2-0.5mg/kg/hr
    • Concentration: Can find in the pharmacy in either 10mg/ml, 50mg/ml or 100mg/ml concentrations. For bolus dosing, I generally like a 10mg/ml concentration. For infusions, I recommend diluting down to 1mg/ml in a 50ml or 100ml bag of NS. 
  • Remifentanil: Narcotic with a potency approximately 2X that of fentanyl. Virtually no context sensitive half-life. Will NOT provide analgesia following case, in fact, patients may experience hyperalgesia. Good for cases when surgeon needs to perform post-op neuro analysis of patient. Usually run in addition to propofol and half MAC of volatile.
    • Infusion: 0.1-0.3 mcg/kg/min
    • Dilution: Comes in a powder 1mg/vial. Mix either 1 or 2 mg in a 100ml bag to make a concentration of 10mcg/ml or 20 mcg/ml 
  • Sufentanil: Narcotic with a potency 10X that of fentanyl. Has a longer context sensitive half-life than that of remifentanyl and shorter than that of fentanyl. Probably the most commonly used at Hermann because it provides some post-op analgesia. Usually run in addition to propofol and  half MAC of volatile.
    • Infusion: 0.1-0.3 mcg/kg/hr
    • Dilution:  Comes in a 2ml glass vial at a concentration of 50mcg/ml (a total of 100mcg per vial) Dilute into a 100ml bag of NS to a concentration of 1mcg/ml. Other institutions will have to dilute to a 5mcg/ml concentration so that a 1ml bolus will be the same as a 1ml bolus of fentanyl.

Vasopressors:

In most situations when using vasopressors and anti-hypertensives, you will generally start on the lower end of the dosing range and titrate up as needed.

  • Phenylephrine: Primarily alpha agonist activity.
    • Infusion: 0.15-0.75mcg/kg/min
      • Many institutions are fine with you making a 250ml bag @ 40mcg/ml and hooking up to a 60 dropper IV tubing and titrating with the roller clamp by hand. Don’t try this at Hermann, however, you’ll likely get in trouble.
    • Dilution: 10mg into 100ml or 250 ml bag to make either 100mcg/ml or 40mcg/ml concentrations.
  • NorEpinephrine: Alpha and beta agonist activity, but more alpha than beta.
    • Infusion: 0.05 – 0.5 mcg/kg/min or 2mcg/min – 10mcg/min (this dosing seen more at other institutions).
    • Dilution: 1 mg into 100ml bag = 10mcg/ml or 4mg into 250ml bag = 16mcg/ml
  • Epinephrine: Alpha and beta agonist activity
    • Infusion: 0.05 – 0.5 mcg/kg/min or 2mcg/min – 10mcg/min (this dosing seen more at other institutions). 
    • Dilution: 1 mg into 100ml bag = 10mcg/ml or 4mg into 250ml bag = 16mcg/ml
  • Vasopressin: Vasopressin is one of the few drugs that regardless of which institution you are in will not be dosed on a per kg basis. Works well in the setting of sepsis, when patients have taken ARB’s or ACE inhibitors on the morning of surgery, and in patients with pulmonary HTN (causes limited pulmonary vasoconstriction in comparison to peripheral vasoconstriction).  
    • Infusion -  1 Unit/hr – 4 Units/hr
    • Dilution – In many hospitals, you can get a 50ml bag @ 1 Unit/ml concentration from the pharmacy. If not, it will come in a 1cc vial @ 20U/ml. Take 5 ml (a total of 100U) and put into a 100ml bag to make a 1U/ml concentration.
  • Dopamine: The function of dopamine is very dose dependent. Below, different infusion rates are labeled with their associated functions.
    • Infusion:
      • Improved renal function(??): 0.5-2.5mcg/kg/min
      • Beta activity: 2.5-10 mcg/kg/min
      • Alpha & Beta: 10-20mcg/kg/min
    • Dilution: 400mg/250ml, 800mg/250ml, 800mg/500ml – All pre-made bags from pharmacy.

Anti- hypertensives:  
  • Nicardipine: Calcium channel blocker. Primarily a vasodilator. Does not depress HR, cardiac contractility or suppress electrical activity in the nodes of the heart. Longer acting than NTG.
    • Infusion: 1-4mcg/kg/min
    • Dilution: 25 mg into a 250ml bag = 100mcg/ml. Usually pre-made by the pharmacy.  
  • Nitroglycerine: Primarily causes venous vasodilation.
    • Infusion: 0.5 – 2mcg/kg/min
    • Dilution: 50mg in a 250ml bag = 200mcg/ml. Generally in pre-made bottle or bag by pharmacy.

Setting up the Pump:

Reading the pump set up on its own really isn't all that helpful. Take some time to play around with the pump when you are actually in the OR. They are not difficult to use, however, it may take a little time and experience getting used to it. If you can pull this up on your phone, it can be a helpful guide in walking you through the step-by-step process. Not every  institution uses the Alaris but many do and it's a good place to start in learning on how to operate pumps in general.

A Alaris pump that is turned off is pictured below. To power it on, simply hold down the "System On" button that is located near the bottom right hand corner of the screen. You may need to hold it for a few seconds until the screen comes on. This would be a good time to make sure that the pump is plugged in as well. Sometimes it will alarm at you if it is not and the battery reaches a low level.

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As the machine powers on, the first screen will ask you if it is a new patient. Press the arrow button located next to the "Yes" icon. After this, it will ask if this is critical care. Again, press the arrow key next to the "Yes" button again. The next screen will prompt you to enter a patient ID. This isn't an important step, so without entering anything press the arrow key at the bottom of the screen that points to the "confirm" button.

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At this step, the pump is technically ready for you to start hooking up drugs and programming infusion rates, but first I want to show you a few things that will make life easier before we move on. To start, we are going to switch the pump into anesthesia mode. This mode allows us to access more drug profiles and will not alarm at you if a channel is paused for an extended period. To switch into anesthesia mode, press the "Options" button near the bottom left hand side of the screen. Next, press the arrow button that points to the "Anesthesia Mode" icon. From here, press the arrow key next to the "Enable" icon, followed by the arrow pointing to the "Confirm" icon. This will take you back to the home screen.

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One more step until we get to the infusion programming. We are going to want to turn down the alarms volumes. The default setting is quite loud and can be annoying to both you and the surgical team. In turning down the volume, you can still hear it, but it won't be as much of a bother. From the home screen, press the arrow at the bottom of the screen next to the "Audio Adjust" icon. At the next screen, press the arrow button next to the "softer" icon until the volume appears to be at its lowest setting. Once you have done this, press the arrow near the "Main Screen" icon to return to the home screen.

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Finally, we are ready to start programming our infusion. There are a number of drugs already programmed in the pump. We will use propofol as our example since it is one commonly used infusion. Programming for other drugs/infusions will essentially be the same with a few subtle differences, so you should be able to use this example in other scenarios.

Begin by pressing the one of the "channel select" buttons on one of the physical pump channels. Either A or B will work, depending on which one you want to start with. Press the arrow key next to "Guardrail Drugs". This will access the drug library already programmed in the pump. You can see a number of drugs in here. To find Propofol, press the arrow key next to the "P-T" icon. The drugs will be organized in alphabetical order. If you don't initially see your drug of choice, you may need to use the "Page up" or "Page down" icons at the bottom of the screen to scroll through your options. Next, press the arrow key next to "propofol." Since this is a commonly used drug at a certain concentration, it is already programmed in the pump and can be seen on the next screen. Some drugs may have multiple options or you may need to manually enter in the concentration. Confirm by pressing the arrow next to the "yes" key.

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The pump will then prompt you for the patient weight. Enter is in kg using the number keypad and then press the "next" arrow. The next screen will ask for a VTBI = volume to be infused and the rate at which you want to run the infusion. Use the arrow keys next to each choice to highlight your selection and enter the associated values. For this example, I have entered 100ml VTBI, a common size of propofol vial, at a rate of 50 mcg/kg/min. When ready, hit the "Start" key followed by the "pause" button on the pump channel.

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Now the pump will be ready for use as soon as we hook up the IV tubing. An example can be seen below of how to hook up the tubing properly to the pump. Once latched in place, if you press the "Restart" button on the pump channel, the infusion will begin to run at the settings you programmed earlier. Now you're ready to roll.

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Note: you can program the pump before or after putting in the IV tubing, the order doesn't really matter. I just chose to program it before placing the tubing in this example.